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VOL. 9, ISSUE 3 (2024)
Toxicity and biochemical activity of chlorobenzothiazole and nitrobenzothiazole derivatives as IGRs against Spodoptera littoralis (Boisd.)
Authors
Naira S Elmasry, Heba M Nasr, Eman A Shehata
Abstract
Benzothiazoles have a broad spectrum of agricultural biological
activities, which are important as heterocyclic structures in agrochemical
applications. The benzothiazole-dihydropyridine and
benzothiazole-dihydropyramidine derivatives are new active ingredients
compounds that were synthesized in a solvent-free by employing a Brønsted
acidic ionic liquid (BAIL gel) as an effective heterogeneous catalyst. Five
compounds were prepared in a range of concentrations (50, 150, 250, 500 and
1000 ppm). Toxicological assay were studied. Data indicated that, diethyl
1-(6-chlorobenzo [d]thiazol-2-yl)-2, 6-diethoxy-4-(4-hydroxyphenyl)-1, 4-dihydropyridine-3,
5-dicarboxylate (4) was approved to be the most toxic compound with LC50
value of 34.02 ppm against 4th instar larvae. compound (1) showed
less toxicity with LC50 value of 191.10 ppm. Also, in case of 1-(6
nitrobenzo [d] thiazol-2-yl)-3-phenyl-2 thioxodihydro pyrimidine-4, 6 (1H, 5H)-dione
(5) showed close toxicity value to that of compound 4, its LC50
value was 35.29 ppm. By using the leaf dip method, the antifeedant activity of
the newly synthesized compounds was evaluated against S. littoralis
larvae. According to enzymes Activities data, all tested compound raised the
level of acetyl cholinesterase in homogenates of larvae in their fourth instar.
It was observed that, compound (4) demonstrated a significant difference when
compared to the control. In α-esterases data, Compounds (4) and (3)
significantly increased the values to79.9 and 62.2%. The results showed that, the
LC50 of compounds (4) resulted in a highly significant decrease in
total protein (-38.2 %). Compounds 1, 2, and 3's LC50 resulted in notable
drops of 12.6, -15.8, and 2.5.4%. Also, compound (5) showed significantly
increased on chitinase activity of 21.2 %. Compounds (5) caused significant
decrease (-29.87%) on activity of phenoloxidase in comparision with control.
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Pages:56-63
How to cite this article:
Naira S Elmasry, Heba M Nasr, Eman A Shehata "Toxicity and biochemical activity of chlorobenzothiazole and nitrobenzothiazole derivatives as IGRs against <i>Spodoptera littoralis</i> (Boisd.)". International Journal of Entomology Research, Vol 9, Issue 3, 2024, Pages 56-63
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